:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --medical-red: #dc3545;
            --medical-green: #198754;
            --medical-yellow: #ffc107;
            --medical-orange: #fd7e14;
            --resistance-low: #198754;
            --resistance-moderate: #ffc107;
            --resistance-high: #fd7e14;
            --resistance-very-high: #dc3545;
        }
         
        .page-header {
            background: linear-gradient(135deg, rgba(169, 214, 229, 0.4) 0%, rgba(44, 125, 160, 0.4) 100%);
            padding: 1.5rem 0;
            margin-bottom: 2rem;
            border-bottom: 1px solid rgba(44, 125, 160, 0.2);
            position: relative;
            overflow: hidden;    color: var(--text-color);
        } 
        .breadcrumb {
            background-color: transparent;
            padding: 0.5rem 0;
            margin-bottom: 0.5rem;
        }
        
        .breadcrumb-item a {
            color: var(--text-muted);
            text-decoration: none;
        }
        
        .breadcrumb-item.active {
            color: var(--text-color);
        }
         
        .invalid-feedback {
            display: none;
            color: var(--medical-red);
            font-size: 0.875rem;
            margin-top: 0.25rem;
        }
         
        .resistance-info-box {
            background-color: rgba(220, 53, 69, 0.05);
            border-left: 3px solid var(--medical-red);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
         
        /* Resistance-specific styling */
        .resistance-alert {
            background-color: rgba(220, 53, 69, 0.1);
            border-left: 4px solid var(--medical-red);
            padding: 1rem;
            margin: 1rem 0;
            border-radius: 0 4px 4px 0;
        }
        
        .resistance-level {
            padding: 1rem;
            border-radius: 8px;
            margin: 1rem 0;
            border-left: 5px solid;
        }
        
        .resistance-low {
            background-color: rgba(25, 135, 84, 0.1);
            border-left-color: var(--resistance-low);
        }
        
        .resistance-moderate {
            background-color: rgba(255, 193, 7, 0.1);
            border-left-color: var(--resistance-moderate);
        }
        
        .resistance-high {
            background-color: rgba(253, 126, 20, 0.1);
            border-left-color: var(--resistance-high);
        }
        
        .resistance-very-high {
            background-color: rgba(220, 53, 69, 0.1);
            border-left-color: var(--resistance-very-high);
        }
        
        .resistance-chart-container {
            position: relative;
            height: 300px;
            width: 100%;
            margin: 1.5rem 0;
        }
        
        .resistance-indicator {
            display: inline-block;
            width: 12px;
            height: 12px;
            border-radius: 50%;
            margin-right: 8px;
        }
        
        .indicator-low {
            background-color: var(--resistance-low);
        }
        
        .indicator-moderate {
            background-color: var(--resistance-moderate);
        }
        
        .indicator-high {
            background-color: var(--resistance-high);
        }
        
        .indicator-very-high {
            background-color: var(--resistance-very-high);
        }
        
        .risk-factor {
            display: flex;
            align-items: center;
            margin-bottom: 0.75rem;
            padding: 0.5rem;
            border-radius: 4px;
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        .risk-factor.active {
            background-color: rgba(220, 53, 69, 0.1);
        }
        
        .risk-factor-icon {
            width: 24px;
            height: 24px;
            border-radius: 50%;
            background-color: var(--light-gray);
            display: flex;
            align-items: center;
            justify-content: center;
            margin-right: 1rem;
            font-size: 0.8rem;
        }
        
        .risk-factor.active .risk-factor-icon {
            background-color: var(--medical-red);
            color: white;
        }
        
        .generating-indicator {
            display: none;
            text-align: center;
            padding: 1rem;
            color: var(--text-muted);
        }
        
        /* Reference table */
        .reference-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .reference-table th, .reference-table td {
            padding: 0.75rem;
            text-align: left;
            border: 1px solid var(--border-color);
        }
        
        .reference-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .reference-table tr:nth-child(even) {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        /* Real-time calculation indicator */
        .real-time-indicator {
            display: none;
            position: absolute;
            top: 10px;
            right: 10px;
            background-color: var(--primary-color);
            color: white;
            padding: 4px 8px;
            border-radius: 4px;
            font-size: 0.75rem;
            font-weight: 600;
        }
        
        .result-container.has-real-time .real-time-indicator {
            display: block;
        }
        
        /* Save case button */
        .save-case-btn {
            position: absolute;
            top: 10px;
            right: 120px;
        }