:root {
            --primary-color: #4a6fa5;
            --secondary-color: #c2d4e8;
            --accent-color: #166088;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --biology-green: #28a745;
            --biology-blue: #17a2b8;
            --biology-purple: #6f42c1;
            --biology-red: #dc3545;
            --biology-yellow: #ffc107;
        }
         
        /* Simulation Canvas */
        .simulation-container {
            display: flex;
            flex-direction: column;
            height: 600px;
            margin-bottom: 2rem;
            border-radius: 8px;
            overflow: hidden;
            border: 1px solid var(--border-color);
            background-color: #f9fbfd;
        }
        
        .simulation-header {
            background-color: var(--light-gray);
            padding: 1rem;
            border-bottom: 1px solid var(--border-color);
            display: flex;
            justify-content: space-between;
            align-items: center;
        }
        
        .simulation-area {
            flex: 1;
            position: relative;
            overflow: hidden;
        }
        
        #pathwayCanvas {
            width: 100%;
            height: 100%;
            display: block;
        }
        
        /* Pathway Controls */
        .pathway-controls {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
            gap: 1.5rem;
            margin-bottom: 2rem;
        }
        
        .control-group {
            background-color: white;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .control-title {
            font-weight: 600;
            margin-bottom: 1rem;
            color: var(--primary-color);
            padding-bottom: 0.5rem;
            border-bottom: 1px solid var(--border-color);
        }
        
        /* Slider Styling */
        .slider-container {
            margin-bottom: 1.25rem;
        }
        
        .slider-label {
            display: flex;
            justify-content: space-between;
            margin-bottom: 0.5rem;
        }
        
        .slider-value {
            background-color: var(--primary-color);
            color: white;
            padding: 0.1rem 0.5rem;
            border-radius: 4px;
            font-size: 0.8rem;
            min-width: 50px;
            text-align: center;
        }
        
        .slider {
            width: 100%;
            height: 6px;
            border-radius: 5px;
            background: #ddd;
            outline: none;
            opacity: 0.7;
            transition: opacity .2s;
        }
        
        .slider:hover {
            opacity: 1;
        }
         
        /* Simulation Controls */
        .simulation-buttons {
            display: flex;
            gap: 1rem;
            flex-wrap: wrap;
            margin-bottom: 1.5rem;
        }
        
        .simulation-btn {
            flex: 1;
            min-width: 120px;
        }
        
        /* Results Section */
        .results-container {
            background-color: white;
            border-radius: 8px;
            border: 1px solid var(--border-color);
            padding: 1.5rem;
            margin-bottom: 2rem;
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .results-header {
            display: flex;
            justify-content: space-between;
            align-items: center;
            margin-bottom: 1.5rem;
        }
        
        .results-charts {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
            gap: 1.5rem;
            margin-bottom: 2rem;
        }
        
        .chart-container {
            background-color: white;
            border-radius: 8px;
            border: 1px solid var(--border-color);
            padding: 1rem;
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .chart-title {
            font-weight: 600;
            margin-bottom: 1rem;
            color: var(--primary-color);
            text-align: center;
        }
        
        .chart-wrapper {
            height: 250px;
            position: relative;
        }
        
        /* Molecular Details */
        .molecule-details {
            background-color: rgba(74, 111, 165, 0.05);
            border-radius: 8px;
            padding: 1.5rem;
            margin-bottom: 2rem;
            border-left: 4px solid var(--primary-color);
        }
        
        .molecule-title {
            font-weight: 600;
            color: var(--primary-color);
            margin-bottom: 1rem;
        }
        
        .molecule-properties {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
            gap: 1rem;
        }
        
        .property {
            display: flex;
            justify-content: space-between;
            padding: 0.5rem 0;
            border-bottom: 1px dashed #ddd;
        }
        
        .property:last-child {
            border-bottom: none;
        }
        
        /* Pathway Cards */
        .pathway-cards {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
            gap: 1.5rem;
            margin-bottom: 2rem;
        }
        
        .pathway-card {
            background-color: white;
            border-radius: 8px;
            border: 1px solid var(--border-color);
            padding: 1.5rem;
            cursor: pointer;
            transition: all 0.3s;
            text-align: center;
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .pathway-card:hover {
            transform: translateY(-5px);
            box-shadow: 0 5px 15px rgba(0,0,0,0.1);
            border-color: var(--primary-color);
        }
        
        .pathway-card.active {
            border-color: var(--primary-color);
            background-color: rgba(74, 111, 165, 0.05);
        }
        
        .pathway-icon {
            width: 60px;
            height: 60px;
            border-radius: 50%;
            background-color: rgba(74, 111, 165, 0.1);
            display: flex;
            align-items: center;
            justify-content: center;
            margin: 0 auto 1rem;
            color: var(--primary-color);
            font-size: 1.5rem;
        }
        
        .pathway-name {
            font-weight: 600;
            margin-bottom: 0.5rem;
            color: var(--primary-color);
        }
         
        .medical-alert {
            background-color: rgba(220, 53, 69, 0.1);
            border-radius: 8px;
            padding: 1.5rem;
            margin: 1.5rem 0;
            border-left: 4px solid var(--biology-red);
        }
         
        .step-content {
            flex: 1;
        }
        
        /* FAQ */
        .faq-section {
            margin-top: 2rem;
        }
          
        
        /* Molecular Node Styling */
        .molecule-node {
            cursor: pointer;
            transition: all 0.3s;
        }
        
        .molecule-node:hover {
            filter: brightness(1.1);
        }
        
        .molecule-node.selected circle {
            stroke: var(--accent-color);
            stroke-width: 3px;
        }
        
        .molecule-label {
            font-size: 12px;
            font-weight: 600;
            text-anchor: middle;
            fill: white;
            pointer-events: none;
            user-select: none;
        }
        
        .pathway-line {
            stroke-width: 2;
            stroke-linecap: round;
        }
        
        .active-pathway {
            animation: pulse 2s infinite;
        }
        
        @keyframes pulse {
            0% { opacity: 0.7; }
            50% { opacity: 1; }
            100% { opacity: 0.7; }
        }
        
        /* Pathway-specific colors */
        .mapk-color {
            fill: var(--biology-red);
        }
        
        .pi3k-color {
            fill: var(--biology-blue);
        }
        
        .jak-stat-color {
            fill: var(--biology-purple);
        }
        
        .wnt-color {
            fill: var(--biology-green);
        }
        
        .nfkb-color {
            fill: var(--biology-yellow);
        }
        
        /* Legend */
        .pathway-legend {
            display: flex;
            flex-wrap: wrap;
            gap: 1rem;
            margin-bottom: 1rem;
        }
        
        .legend-item {
            display: flex;
            align-items: center;
            gap: 0.5rem;
        }
        
        .legend-color {
            width: 16px;
            height: 16px;
            border-radius: 4px;
        }
        
        .legend-label {
            font-size: 0.9rem;
            color: var(--text-color);
        }
        
        /* Loading Indicator */
        .loading-indicator {
            display: none;
            position: absolute;
            top: 50%;
            left: 50%;
            transform: translate(-50%, -50%);
            background-color: rgba(255, 255, 255, 0.9);
            padding: 1.5rem;
            border-radius: 8px;
            box-shadow: 0 5px 15px rgba(0,0,0,0.1);
            text-align: center;
            z-index: 1000;
        }
        
        /* Responsive Adjustments */
        @media (max-width: 768px) { 
            .simulation-container {
                height: 400px;
            }
            
            .pathway-controls {
                grid-template-columns: 1fr;
            }
            
            .results-charts {
                grid-template-columns: 1fr;
            }
            
            .action-buttons {
                margin-top: 1rem;
            }
        }