:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --medical-red: #dc3545;
            --medical-green: #198754;
            --medical-yellow: #ffc107;
            --medical-orange: #fd7e14;
            --biochemistry-purple: #6f42c1;
            --biochemistry-teal: #20c997;
        }
         
        .page-header {
            background: linear-gradient(135deg, rgba(169, 214, 229, 0.4) 0%, rgba(44, 125, 160, 0.4) 100%);
            padding: 1.5rem 0;
            margin-bottom: 2rem;
            border-bottom: 1px solid rgba(44, 125, 160, 0.2);
            position: relative;
            overflow: hidden;    color: var(--text-color);
        }
         
        
        .breadcrumb {
            background-color: transparent;
            padding: 0.5rem 0;
            margin-bottom: 0.5rem;
        }
        
        .breadcrumb-item a {
            color: var(--text-muted);
            text-decoration: none;
        }
        
        .breadcrumb-item.active {
            color: var(--text-color);
        }
          
        .medical-info-box {
            background-color: rgba(220, 53, 69, 0.05);
            border-left: 3px solid var(--medical-red);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
         
 
        
        /* Toggle switch for calculation modes */
        .calculation-modes {
            display: flex;
            background-color: var(--light-gray);
            border-radius: 6px;
            padding: 4px;
            margin-bottom: 1.5rem;
            flex-wrap: wrap;
        }
        
        .mode-btn {
            flex: 1;
            text-align: center;
            padding: 0.75rem;
            border-radius: 4px;
            cursor: pointer;
            transition: all 0.3s;
            font-weight: 600;
            min-width: 120px;
            margin: 2px;
        }
        
        .mode-btn.active {
            background-color: var(--primary-color);
            color: white;
        }
         
        /* Data table styling */
        .data-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .data-table th, .data-table td {
            padding: 0.75rem;
            text-align: left;
            border-bottom: 1px solid var(--border-color);
        }
        
        .data-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .data-table tr:hover {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        /* Biochemistry-specific styling */
        .biochemistry-box {
            background-color: rgba(111, 66, 193, 0.05);
            border-left: 3px solid var(--biochemistry-purple);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
        
        .biochemistry-alert {
            background-color: rgba(32, 201, 151, 0.1);
            border-left: 4px solid var(--biochemistry-teal);
            padding: 1rem;
            margin: 1rem 0;
            border-radius: 0 4px 4px 0;
        }
        
        .reference-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .reference-table th, .reference-table td {
            padding: 0.75rem;
            text-align: left;
            border: 1px solid var(--border-color);
        }
        
        .reference-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .reference-table tr:nth-child(even) {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        .generating-indicator {
            display: none;
            text-align: center;
            padding: 1rem;
            color: var(--text-muted);
        }
        
        /* Enzyme kinetics specific styles */
        .kinetics-input-group {
            display: flex;
            align-items: center;
            margin-bottom: 1rem;
        }
        
        .kinetics-input {
            width: 120px;
            margin-right: 1rem;
        }
        
        .kinetics-separator {
            font-size: 1.5rem;
            font-weight: bold;
            color: var(--text-muted);
            margin: 0 0.5rem;
        }
        
        .parameter-box {
            padding: 1rem;
            border-radius: 8px;
            margin: 1rem 0;
            border-left: 5px solid;
        }
        
        .parameter-normal {
            background-color: rgba(40, 167, 69, 0.1);
            border-left-color: var(--medical-green);
        }
        
        .parameter-elevated {
            background-color: rgba(255, 193, 7, 0.1);
            border-left-color: var(--medical-yellow);
        }
        
        .parameter-high {
            background-color: rgba(253, 126, 20, 0.1);
            border-left-color: var(--medical-orange);
        }
        
        .parameter-extreme {
            background-color: rgba(220, 53, 69, 0.1);
            border-left-color: var(--medical-red);
        }
        
        .kinetics-chart-container {
            position: relative;
            height: 300px;
            width: 100%;
            margin: 1.5rem 0;
        }
        
        .parameter-indicator {
            display: inline-block;
            width: 12px;
            height: 12px;
            border-radius: 50%;
            margin-right: 8px;
        }
        
        .parameter-normal-indicator {
            background-color: var(--medical-green);
        }
        
        .parameter-elevated-indicator {
            background-color: var(--medical-yellow);
        }
        
        .parameter-high-indicator {
            background-color: var(--medical-orange);
        }
        
        .parameter-extreme-indicator {
            background-color: var(--medical-red);
        }
        
        .data-point-row {
            display: flex;
            margin-bottom: 10px;
            align-items: center;
        }
        
        .data-point-input {
            width: 120px;
            margin-right: 15px;
        }
        
        .remove-data-point {
            background: none;
            border: none;
            color: var(--medical-red);
            cursor: pointer;
        }
        
        .add-data-point {
            margin-top: 10px;
        }
        
        .data-entry-container {
            max-height: 300px;
            overflow-y: auto;
            padding: 10px;
            border: 1px solid var(--border-color);
            border-radius: 6px;
            margin-bottom: 1rem;
        }
        
        /* Tab styling */
        .nav-tabs {
            border-bottom: 1px solid var(--border-color);
            margin-bottom: 1.5rem;
        }
        
        .nav-tabs .nav-link {
            border: none;
            color: var(--text-muted);
            font-weight: 500;
        }
        
        .nav-tabs .nav-link.active {
            color: var(--primary-color);
            border-bottom: 2px solid var(--primary-color);
            background-color: transparent;
        }
        
        .tab-content {
            padding: 0;
        }