:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --bio-green: #198754;
            --bio-blue: #0d6efd;
            --bio-purple: #6f42c1;
            --bio-red: #dc3545;
        }
      
        
        /* Pathway Visualization Container */
        .pathway-container {
            background-color: white;
            border-radius: 8px;
            border: 1px solid var(--border-color);
            padding: 1.5rem;
            margin-bottom: 1.5rem;
            box-shadow: 0 2px 10px rgba(0,0,0,0.05);
            height: 600px;
            position: relative;
            overflow: hidden;
        }
        
        #pathway-canvas {
            width: 100%;
            height: 100%;
            background-color: #f8f9fa;
            border-radius: 4px;
        }
        
        /* Controls Panel */
        .controls-panel {
            background-color: var(--light-gray);
            border-radius: 8px;
            padding: 1.5rem;
            margin-bottom: 1.5rem;
            border: 1px solid var(--border-color);
        }
        
        /* Legend */
        .legend {
            display: flex;
            flex-wrap: wrap;
            gap: 1rem;
            margin-top: 1rem;
        }
        
        .legend-item {
            display: flex;
            align-items: center;
            font-size: 0.9rem;
        }
        
        .legend-color {
            width: 16px;
            height: 16px;
            border-radius: 4px;
            margin-right: 0.5rem;
        }
        
        /* Node Info Panel */
        .node-info {
            background-color: white;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            box-shadow: 0 2px 10px rgba(0,0,0,0.05);
            max-height: 400px;
            overflow-y: auto;
            position: relative;
        }
        
        .node-info.hidden {
            display: none;
        }
        
        .close-btn {
            position: absolute;
            top: 10px;
            right: 15px;
            background: none;
            border: none;
            font-size: 1.2rem;
            cursor: pointer;
            color: var(--text-muted);
        }
        
        /* Search Results */
        .search-results {
            max-height: 300px;
            overflow-y: auto;
            border: 1px solid var(--border-color);
            border-radius: 6px;
            margin-top: 1rem;
        }
        
        .search-result-item {
            padding: 0.75rem;
            border-bottom: 1px solid var(--border-color);
            cursor: pointer;
            transition: background-color 0.2s;
        }
        
        .search-result-item:hover {
            background-color: var(--light-gray);
        }
        
        .search-result-item:last-child {
            border-bottom: none;
        }
        
        /* Content Sections */
        .section-title {
            font-weight: 600;
            margin-bottom: 1rem;
            color: var(--primary-color);
            padding-bottom: 0.5rem;
            border-bottom: 1px solid var(--border-color);
        }
        
        .info-box {
            background-color: rgba(44, 125, 160, 0.05);
            border-left: 3px solid var(--primary-color);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
        
        /* Pathway Navigation */
        .pathway-nav {
            display: flex;
            gap: 1rem;
            margin-bottom: 1.5rem;
            flex-wrap: wrap;
        }
        
        .nav-btn {
            padding: 0.5rem 1rem;
            border-radius: 6px;
            border: 1px solid var(--border-color);
            background: white;
            cursor: pointer;
            transition: all 0.2s;
            font-weight: 500;
        }
        
        .nav-btn:hover {
            background-color: var(--light-gray);
        }
        
        .nav-btn.active {
            background-color: var(--primary-color);
            color: white;
            border-color: var(--primary-color);
        }
        
        /* Analysis Panel */
        .analysis-panel {
            background-color: white;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            margin-bottom: 1.5rem;
            box-shadow: 0 2px 10px rgba(0,0,0,0.05);
        }
        
        .metric-card {
            background: var(--light-gray);
            border-radius: 6px;
            padding: 1rem;
            text-align: center;
        }
        
        .metric-value {
            font-size: 1.5rem;
            font-weight: 700;
            color: var(--primary-color);
            margin-bottom: 0.25rem;
        }
        
        .metric-label {
            font-size: 0.9rem;
            color: var(--text-muted);
        }
        
        /* Zoom Controls */
        .zoom-controls {
            position: absolute;
            bottom: 20px;
            right: 20px;
            background: white;
            border-radius: 6px;
            padding: 0.5rem;
            box-shadow: 0 2px 10px rgba(0,0,0,0.1);
            border: 1px solid var(--border-color);
            display: flex;
            flex-direction: column;
            gap: 0.5rem;
        }
        
        .zoom-btn {
            width: 36px;
            height: 36px;
            border-radius: 4px;
            border: 1px solid var(--border-color);
            background: white;
            display: flex;
            align-items: center;
            justify-content: center;
            cursor: pointer;
            transition: all 0.2s;
        }
        
        .zoom-btn:hover {
            background-color: var(--light-gray);
        }
        
        /* Tooltip */
        .tooltip {
            position: absolute;
            background: rgba(0, 0, 0, 0.8);
            color: white;
            padding: 0.5rem;
            border-radius: 4px;
            font-size: 0.9rem;
            pointer-events: none;
            z-index: 1000;
            max-width: 300px;
        }
        
        /* Highlight effects */
        .highlighted {
            filter: drop-shadow(0 0 8px rgba(255, 193, 7, 0.7));
        }
        
        /* Validation Panel */
        .validation-panel {
            background-color: #f8f9fa;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            margin-bottom: 1.5rem;
        }
        
        .test-case {
            padding: 1rem;
            border-radius: 6px;
            border: 1px solid var(--border-color);
            margin-bottom: 1rem;
            background-color: white;
        }
        
        .test-result {
            display: inline-block;
            padding: 0.25rem 0.75rem;
            border-radius: 4px;
            font-weight: 600;
            font-size: 0.9rem;
        }
        
        .test-pass {
            background-color: rgba(40, 167, 69, 0.1);
            color: var(--success-color);
        }
        
        .test-fail {
            background-color: rgba(220, 53, 69, 0.1);
            color: var(--bio-red);
        }