:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --chemistry-blue: #0d6efd;
            --chemistry-green: #198754;
            --chemistry-yellow: #ffc107;
            --chemistry-orange: #fd7e14;
            --bioinformatics-purple: #6f42c1;
        }
          
        /* Chart Container */
        .chart-container {
            position: relative;
            height: 400px;
            width: 100%;
            margin: 2rem 0;
        }
         
        .bioinformatics-info-box {
            background-color: rgba(111, 66, 193, 0.05);
            border-left: 3px solid var(--bioinformatics-purple);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
        
        /* Toggle switch for calculation modes */
        .calculation-modes {
            display: flex;
            background-color: var(--light-gray);
            border-radius: 6px;
            padding: 4px;
            margin-bottom: 1.5rem;
            flex-wrap: wrap;
        }
        
        .mode-btn {
            flex: 1;
            text-align: center;
            padding: 0.75rem;
            border-radius: 4px;
            cursor: pointer;
            transition: all 0.3s;
            font-weight: 600;
            min-width: 120px;
            margin: 2px;
        }
        
        .mode-btn.active {
            background-color: var(--primary-color);
            color: white;
        }
         
        
        /* Docking specific styles */
        .docking-input-group {
            display: flex;
            align-items: center;
            margin-bottom: 1rem;
        }
        
        .docking-input {
            width: 120px;
            margin-right: 1rem;
        }
        
        .docking-classification {
            padding: 1rem;
            border-radius: 8px;
            margin: 1rem 0;
            border-left: 5px solid;
        }
        
        .docking-high-affinity {
            background-color: rgba(40, 167, 69, 0.1);
            border-left-color: var(--chemistry-green);
        }
        
        .docking-medium-affinity {
            background-color: rgba(255, 193, 7, 0.1);
            border-left-color: var(--chemistry-yellow);
        }
        
        .docking-low-affinity {
            background-color: rgba(253, 126, 20, 0.1);
            border-left-color: var(--chemistry-orange);
        }
        
        .docking-very-low-affinity {
            background-color: rgba(220, 53, 69, 0.1);
            border-left-color: var(--medical-red);
        }
        
        .docking-chart-container {
            position: relative;
            height: 300px;
            width: 100%;
            margin: 1.5rem 0;
        }
        
        .docking-status-indicator {
            display: inline-block;
            width: 12px;
            height: 12px;
            border-radius: 50%;
            margin-right: 8px;
        }
        
        .status-high-affinity {
            background-color: var(--chemistry-green);
        }
        
        .status-medium-affinity {
            background-color: var(--chemistry-yellow);
        }
        
        .status-low-affinity {
            background-color: var(--chemistry-orange);
        }
        
        .status-very-low-affinity {
            background-color: var(--medical-red);
        }
        
        /* Table for docking data */
        .docking-data-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .docking-data-table th, .docking-data-table td {
            padding: 0.75rem;
            text-align: left;
            border: 1px solid var(--border-color);
        }
        
        .docking-data-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .docking-data-table tr:nth-child(even) {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        /* Visualization placeholder */
        .visualization-container {
            background-color: #f8f9fa;
            border-radius: 8px;
            padding: 1.5rem;
            margin: 1.5rem 0;
            text-align: center;
            border: 1px solid var(--border-color);
        }
        
        .visualization-placeholder {
            width: 100%;
            height: 300px;
            background: linear-gradient(135deg, #e9ecef 0%, #dee2e6 100%);
            border-radius: 6px;
            display: flex;
            flex-direction: column;
            align-items: center;
            justify-content: center;
            color: var(--text-muted);
            font-weight: 500;
            margin-bottom: 1rem;
        }
        
        .visualization-placeholder i {
            font-size: 3rem;
            margin-bottom: 1rem;
            color: var(--bioinformatics-purple);
        }
        
        /* Progress bar for docking simulation */
        .progress-container {
            margin: 1.5rem 0;
        }
        
        .progress {
            height: 10px;
            border-radius: 5px;
            margin-bottom: 0.5rem;
        }
        
        .progress-label {
            display: flex;
            justify-content: space-between;
            font-size: 0.9rem;
            color: var(--text-muted);
        }
        
        /* Interaction forces styling */
        .interaction-forces {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
            gap: 1rem;
            margin: 1.5rem 0;
        }
        
        .interaction-item {
            background: white;
            border-radius: 8px;
            padding: 1rem;
            border: 1px solid var(--border-color);
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
            text-align: center;
        }
        
        .interaction-value {
            font-size: 1.25rem;
            font-weight: 700;
            color: var(--bioinformatics-purple);
            margin-bottom: 0.25rem;
        }
        
        .interaction-label {
            color: var(--text-muted);
            font-size: 0.9rem;
        }
        
        /* Protein and ligand cards */
        .molecule-card {
            background: white;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            margin-bottom: 1.5rem;
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .molecule-header {
            display: flex;
            align-items: center;
            margin-bottom: 1rem;
        }
        
        .molecule-icon {
            width: 40px;
            height: 40px;
            border-radius: 8px;
            background-color: rgba(111, 66, 193, 0.1);
            display: flex;
            align-items: center;
            justify-content: center;
            margin-right: 1rem;
            color: var(--bioinformatics-purple);
            font-size: 1.25rem;
        }
        
        .molecule-properties {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(150px, 1fr));
            gap: 1rem;
        }
        
        .property-item {
            text-align: center;
            padding: 0.75rem;
            background-color: var(--light-gray);
            border-radius: 6px;
        }
        
        .property-value {
            font-weight: 600;
            color: var(--primary-color);
            margin-bottom: 0.25rem;
        }
        
        .property-label {
            color: var(--text-muted);
            font-size: 0.85rem;
        }