:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --medical-red: #dc3545;
            --medical-green: #198754;
            --medical-yellow: #ffc107;
            --medical-orange: #fd7e14;
        }
         
        .mode-form{display:none} .active{display:block}
         
        .medical-info-box {
            background-color: rgba(220, 53, 69, 0.05);
            border-left: 3px solid var(--medical-red);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
         
        /* Toggle switch for calculation modes */
        .calculation-modes {
            display: flex;
            background-color: var(--light-gray);
            border-radius: 6px;
            padding: 4px;
            margin-bottom: 1.5rem;
            flex-wrap: wrap;
        }
        
        .mode-btn {
            flex: 1;
            text-align: center;
            padding: 0.75rem;
            border-radius: 4px;
            cursor: pointer;
            transition: all 0.3s;
            font-weight: 600;
            min-width: 120px;
            margin: 2px;
        }
        
        .mode-btn.active {
            background-color: var(--primary-color);
            color: white;
        }
        
        /* Toast notifications */
        .toast-container {
            position: fixed;
            bottom: 20px;
            right: 20px;
            z-index: 1050;
        }
         
        /* Mutation Rate specific styling */
        .mutation-alert {
            background-color: rgba(220, 53, 69, 0.1);
            border-left: 4px solid var(--medical-red);
            padding: 1rem;
            margin: 1rem 0;
            border-radius: 0 4px 4px 0;
        }
        
        .normal-range {
            color: var(--medical-green);
            font-weight: 600;
        }
        
        .abnormal-range {
            color: var(--medical-red);
            font-weight: 600;
        }
        
        .reference-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .reference-table th, .reference-table td {
            padding: 0.75rem;
            text-align: left;
            border: 1px solid var(--border-color);
        }
        
        .reference-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .reference-table tr:nth-child(even) {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        .generating-indicator {
            display: none;
            text-align: center;
            padding: 1rem;
            color: var(--text-muted);
        }
        
        /* Mutation rate specific styles */
        .mutation-input-group {
            display: flex;
            align-items: center;
            margin-bottom: 1rem;
        }
        
        .mutation-input {
            width: 120px;
            margin-right: 1rem;
        }
        
        .mutation-chart-container {
            position: relative;
            height: 300px;
            width: 100%;
            margin: 1.5rem 0;
        }
        
        .mutation-status-indicator {
            display: inline-block;
            width: 12px;
            height: 12px;
            border-radius: 50%;
            margin-right: 8px;
        }
        
        .status-low {
            background-color: var(--medical-green);
        }
        
        .status-medium {
            background-color: var(--medical-yellow);
        }
        
        .status-high {
            background-color: var(--medical-orange);
        }
        
        .status-very-high {
            background-color: var(--medical-red);
        }
        
        .sample-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1rem 0;
        }
        
        .sample-table th, .sample-table td {
            padding: 0.5rem;
            text-align: center;
            border: 1px solid var(--border-color);
        }
        
        .sample-table th {
            background-color: var(--light-gray);
        }
        
        .sample-table input {
            width: 100%;
            border: none;
            text-align: center;
            padding: 0.25rem;
        }
        
        .statistics-box {
            background-color: rgba(44, 125, 160, 0.05);
            border-radius: 6px;
            padding: 1rem;
            margin: 1rem 0;
        }
        
        .statistics-row {
            display: flex;
            justify-content: space-between;
            margin-bottom: 0.5rem;
        }
        
        .statistics-label {
            font-weight: 600;
        }
        
        .statistics-value {
            font-weight: 600;
            color: var(--primary-color);
        }
        
        .sample-row {
            display: flex;
            margin-bottom: 1rem;
            padding-bottom: 1rem;
            border-bottom: 1px solid var(--border-color);
        }
        
        .sample-name {
            width: 150px;
            font-weight: 600;
        }
        
        .sample-values {
            flex: 1;
        }
        
        .sample-input {
            width: 100px;
            display: inline-block;
            margin-right: 1rem;
        }
        
        .model-selection {
            display: flex;
            flex-wrap: wrap;
            gap: 10px;
            margin-bottom: 1rem;
        }
        
        .model-option {
            flex: 1;
            min-width: 120px;
        }
        
        .model-option input {
            margin-right: 5px;
        }

        /* Confidence interval styling */
        .confidence-interval {
            background-color: rgba(33, 37, 41, 0.03);
            border-left: 3px solid var(--warning-color);
            padding: 0.75rem;
            margin: 1rem 0;
            border-radius: 0 4px 4px 0;
        }

        .confidence-interval .interval-value {
            font-weight: 600;
            color: var(--warning-color);
        }

        .invalid-feedback {
            display: none;
            color: var(--medical-red);
            font-size: 0.875em;
            margin-top: 0.25rem;
        }

        .is-invalid {
            border-color: var(--medical-red);
        }

        .is-valid {
            border-color: var(--medical-green);
        }