:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --danger-color: #dc3545;
            --dna-blue: #3a86ff;
            --dna-green: #38b000;
            --dna-red: #e63946;
            --dna-purple: #8338ec;
            --dna-yellow: #ffbe0b;
        }
         
        .page-header {
            background: linear-gradient(135deg, rgba(169, 214, 229, 0.4) 0%, rgba(44, 125, 160, 0.4) 100%);
            padding: 1.5rem 0;
            margin-bottom: 2rem;
            border-bottom: 1px solid rgba(44, 125, 160, 0.2);
            position: relative;
            overflow: hidden;     color: var(--text-color);
        }
        
        .breadcrumb {
            background-color: transparent;
            padding: 0.5rem 0;
            margin-bottom: 0.5rem;
        }
        
        .breadcrumb-item a {
            color: var(--text-muted);
            text-decoration: none;
        }
        
        .breadcrumb-item.active {
            color: var(--text-color);
        }
         
        /* Canvas Container */
        .canvas-container {
            background-color: white;
            border-radius: 8px;
            border: 1px solid var(--border-color);
            padding: 1rem;
            margin-bottom: 1.5rem;
            height: 600px;
            position: relative;
            overflow: hidden;
        }
        
        #plasmidCanvas {
            width: 100%;
            height: 100%;
            display: block;
        }
        
        .canvas-controls {
            position: absolute;
            top: 20px;
            right: 20px;
            background: rgba(255, 255, 255, 0.9);
            border-radius: 6px;
            padding: 0.5rem;
            box-shadow: 0 2px 8px rgba(0,0,0,0.1);
            z-index: 10;
        }
        
        .canvas-controls button {
            margin: 2px;
        }
        
        /* Plasmid Controls */
        .plasmid-controls {
            display: flex;
            flex-wrap: wrap;
            gap: 1rem;
            margin-bottom: 1.5rem;
        }
        
        .control-group {
            flex: 1;
            min-width: 200px;
        }
        
        .control-group label {
            font-weight: 600;
            margin-bottom: 0.5rem;
            display: block;
        }
        
        /* Element List */
        .element-list {
            max-height: 400px;
            overflow-y: auto;
            border: 1px solid var(--border-color);
            border-radius: 6px;
            margin-bottom: 1.5rem;
        }
        
        .element-item {
            padding: 0.75rem 1rem;
            border-bottom: 1px solid var(--border-color);
            display: flex;
            align-items: center;
            cursor: pointer;
            transition: background-color 0.2s;
        }
        
        .element-item:hover {
            background-color: var(--light-gray);
        }
        
        .element-item:last-child {
            border-bottom: none;
        }
        
        .element-color {
            width: 16px;
            height: 16px;
            border-radius: 3px;
            margin-right: 10px;
            border: 1px solid rgba(0,0,0,0.1);
        }
        
        .element-name {
            font-weight: 500;
            flex-grow: 1;
        }
        
        .element-length {
            color: var(--text-muted);
            font-size: 0.9rem;
        }
        
        /* Button Styles */
        .btn-primary {
            background-color: var(--primary-color);
            border-color: var(--primary-color);
            font-weight: 600;
            padding: 0.75rem 1.5rem;
            border-radius: 6px;
            transition: all 0.3s;
        }
        
        .btn-primary:hover {
            background-color: var(--accent-color);
            border-color: var(--accent-color);
            transform: translateY(-1px);
        }
        
        .btn-outline-secondary {
            font-weight: 600;
            border-radius: 6px;
            padding: 0.75rem 1.5rem;
        }
        
        /* Form Styles */
        .form-label {
            font-weight: 600;
            margin-bottom: 0.5rem;
            color: var(--text-color);
        }
        
        .form-control {
            border: 1px solid #ddd;
            border-radius: 6px;
            padding: 0.75rem;
            transition: all 0.3s;
        }
        
        .form-control:focus {
            border-color: var(--primary-color);
            box-shadow: 0 0 0 3px rgba(44, 125, 160, 0.15);
        }
        
        /* Modal Styles */
        .modal-content {
            border-radius: 8px;
            border: none;
            box-shadow: 0 10px 30px rgba(0,0,0,0.2);
        }
        
        .modal-header {
            background-color: var(--primary-color);
            color: white;
            border-radius: 8px 8px 0 0;
            padding: 1rem 1.5rem;
        }
        
        .modal-title {
            font-weight: 600;
        }
       
        
        /* Responsive Adjustments */
        @media (max-width: 768px) { 
            .plasmid-controls {
                flex-direction: column;
            }
            
            .canvas-container {
                height: 400px;
            }
        }
        
        /* Element type colors */
        .promoter-color { background-color: var(--dna-red); }
        .gene-color { background-color: var(--dna-blue); }
        .resistance-color { background-color: var(--dna-green); }
        .origin-color { background-color: var(--dna-purple); }
        .restriction-color { background-color: var(--dna-yellow); }
        .tag-color { background-color: #9d4edd; }
        .terminator-color { background-color: #f72585; }
        
        /* Element form */
        .element-form-group {
            margin-bottom: 1rem;
        }
        
        .color-preview {
            width: 30px;
            height: 30px;
            border-radius: 4px;
            display: inline-block;
            margin-right: 10px;
            vertical-align: middle;
            border: 1px solid rgba(0,0,0,0.2);
        }
        
        /* Element details panel */
        .element-details {
            background-color: var(--light-gray);
            border-radius: 6px;
            padding: 1.5rem;
            margin-top: 1.5rem;
            border: 1px solid var(--border-color);
        }
        
        .element-details h5 {
            color: var(--primary-color);
            margin-bottom: 1rem;
        }
        
        .details-row {
            display: flex;
            margin-bottom: 0.5rem;
        }
        
        .details-label {
            font-weight: 600;
            width: 120px;
        }
        
        .details-value {
            flex-grow: 1;
        }
        
        /* Plasmid info */
        .plasmid-info {
            display: flex;
            flex-wrap: wrap;
            gap: 1rem;
            margin-bottom: 1.5rem;
        }
        
        .plasmid-info-item {
            background: white;
            border-radius: 6px;
            padding: 1rem;
            border: 1px solid var(--border-color);
            flex: 1;
            min-width: 150px;
        }
        
        .plasmid-info-label {
            font-size: 0.9rem;
            color: var(--text-muted);
            margin-bottom: 0.25rem;
        }
        
        .plasmid-info-value {
            font-size: 1.25rem;
            font-weight: 700;
            color: var(--primary-color);
        }
        
        /* Draggable element */
        .draggable-element {
            padding: 0.5rem 1rem;
            background-color: white;
            border: 2px dashed var(--border-color);
            border-radius: 6px;
            margin-bottom: 0.5rem;
            cursor: move;
            transition: all 0.2s;
            display: flex;
            align-items: center;
        }
        
        .draggable-element:hover {
            border-color: var(--primary-color);
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        .draggable-icon {
            margin-right: 10px;
            font-size: 1.2rem;
        }
        
        /* Feature table */
        .feature-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1rem 0;
        }
        
        .feature-table th, .feature-table td {
            padding: 0.75rem;
            text-align: left;
            border-bottom: 1px solid var(--border-color);
        }
        
        .feature-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .feature-table tr:hover {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        .feature-color {
            width: 16px;
            height: 16px;
            border-radius: 3px;
            display: inline-block;
            margin-right: 8px;
        }
        
        .download-options {
            display: flex;
            flex-wrap: wrap;
            gap: 0.5rem;
            margin-top: 1rem;
        }
        
        .download-btn {
            flex: 1;
            min-width: 120px;
        }
        
        /* Sequence viewer */
        .sequence-viewer {
            font-family: 'Courier New', monospace;
            background-color: #f8f9fa;
            border-radius: 6px;
            padding: 1rem;
            margin-top: 1rem;
            max-height: 300px;
            overflow-y: auto;
            border: 1px solid var(--border-color);
            font-size: 0.9rem;
            line-height: 1.4;
        }
        
        .sequence-line {
            margin-bottom: 0.5rem;
        }
        
        .sequence-position {
            color: var(--text-muted);
            font-weight: 600;
            margin-right: 1rem;
            display: inline-block;
            width: 60px;
        }
        
        /* Restriction site finder */
        .enzyme-list {
            max-height: 300px;
            overflow-y: auto;
            border: 1px solid var(--border-color);
            border-radius: 6px;
            margin-top: 1rem;
        }
        
        .enzyme-item {
            padding: 0.5rem 1rem;
            border-bottom: 1px solid var(--border-color);
            display: flex;
            align-items: center;
        }
        
        .enzyme-item:last-child {
            border-bottom: none;
        }
        
        .enzyme-checkbox {
            margin-right: 10px;
        }
        
        .enzyme-name {
            font-weight: 500;
            flex-grow: 1;
        }
        
        .enzyme-site {
            color: var(--text-muted);
            font-family: 'Courier New', monospace;
            font-size: 0.9rem;
        }