:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --danger-color: #dc3545;
        }
         .financial-item .value{word-break:break-all}
        .page-header {
            background: linear-gradient(135deg, rgba(169, 214, 229, 0.4) 0%, rgba(44, 125, 160, 0.4) 100%);
            padding: 1.5rem 0;
            margin-bottom: 2rem;
            border-bottom: 1px solid rgba(44, 125, 160, 0.2);
            position: relative;
            overflow: hidden;    color: var(--text-color);
        } 
        .breadcrumb {
            background-color: transparent;
            padding: 0.5rem 0;
            margin-bottom: 0.5rem;
        }
        
        .breadcrumb-item a {
            color: var(--text-muted);
            text-decoration: none;
        }
        
        .breadcrumb-item.active {
            color: var(--text-color);
        }
          
        /* Toggle switch for calculation modes */
        .calculation-modes {
            display: flex;
            background-color: var(--light-gray);
            border-radius: 6px;
            padding: 4px;
            margin-bottom: 1.5rem;
            flex-wrap: wrap;
        }
        
        .mode-btn {
            flex: 1;
            text-align: center;
            padding: 0.75rem;
            border-radius: 4px;
            cursor: pointer;
            transition: all 0.3s;
            font-weight: 600;
            min-width: 120px;
            margin: 2px;
        }
        
        .mode-btn.active {
            background-color: var(--primary-color);
            color: white;
        }
         
        /* Mode-specific form styling */
        .mode-form {
            display: none;
        }
        
        .mode-form.active {
            display: block;
        }
        
        /* Sequence Visualization */
        .sequence-container {
            background-color: #f8f9fa;
            border-radius: 6px;
            padding: 1rem;
            font-family: monospace;
            font-size: 1.1rem;
            line-height: 1.8;
            overflow-x: auto;
            white-space: nowrap;
            margin: 1rem 0;
        }
        
        .sequence-base {
            display: inline-block;
            width: 1.5rem;
            text-align: center;
            font-weight: 600;
        }
        
        .base-a { color: #28a745; }
        .base-t { color: #dc3545; }
        .base-c { color: #007bff; }
        .base-g { color: #6f42c1; }
        
        .primer-highlight {
            background-color: rgba(255, 193, 7, 0.3);
            border-radius: 3px;
        }
        
        /* Primer Table */
        .primer-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .primer-table th, .primer-table td {
            padding: 0.75rem;
            text-align: left;
            border-bottom: 1px solid var(--border-color);
        }
        
        .primer-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .primer-table tr:hover {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        .primer-valid {
            color: var(--success-color);
        }
        
        .primer-warning {
            color: var(--warning-color);
        }
        
        .primer-error {
            color: var(--danger-color);
        }
        
        /* Parameter cards */
        .parameter-card {
            background-color: white;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            margin-bottom: 1.5rem;
        }
        
        .parameter-group {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
            gap: 1rem;
            margin-bottom: 1rem;
        }
        
        /* Range slider styling */
        .form-range {
            width: 100%;
            height: 1rem;
            padding: 0;
            background-color: transparent;
            -webkit-appearance: none;
        }
        
        .form-range:focus {
            outline: none;
        }
        
        .form-range::-webkit-slider-thumb {
            width: 1rem;
            height: 1rem;
            margin-top: -0.5rem;
            background-color: var(--primary-color);
            border: 0;
            border-radius: 1rem;
            -webkit-appearance: none;
        }
        
        .form-range::-webkit-slider-runnable-track {
            width: 100%;
            height: 0.5rem;
            cursor: pointer;
            animate: 0.2s;
            background: var(--light-gray);
            border-radius: 0.5rem;
        }
        
        .slider-value {
            background-color: var(--primary-color);
            color: white;
            padding: 0.25rem 0.5rem;
            border-radius: 4px;
            font-size: 0.8rem;
            margin-left: 0.5rem;
        }
        
        .slider-container {
            display: flex;
            align-items: center;
            margin-bottom: 1rem;
        }
       
        /* Nucleotide input styling */
        .sequence-input {
            font-family: monospace;
            font-size: 1.1rem;
            min-height: 150px;
        }
        
        /* Primer analysis results */
        .analysis-result {
            padding: 1rem;
            border-radius: 6px;
            margin-bottom: 1rem;
        }
        
        .analysis-good {
            background-color: rgba(40, 167, 69, 0.1);
            border-left: 4px solid var(--success-color);
        }
        
        .analysis-warning {
            background-color: rgba(255, 193, 7, 0.1);
            border-left: 4px solid var(--warning-color);
        }
        
        .analysis-error {
            background-color: rgba(220, 53, 69, 0.1);
            border-left: 4px solid var(--danger-color);
        }
        
        /* Responsive Adjustments */
        @media (max-width: 768px) { 
            
            .parameter-group {
                grid-template-columns: 1fr;
            }
            
            .financial-summary {
                grid-template-columns: 1fr;
            }
        }