:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --danger-color: #dc3545;
            --biology-green: #198754;
            --biology-blue: #0d6efd;
            --biology-purple: #6f42c1;
        }
          .reference-table {
    width: 100%;
    border-collapse: collapse;
    margin: 1.5rem 0;
}.reference-table th {
    background-color: var(--light-gray);
    font-weight: 600;
}
.reference-table th, .reference-table td {
    padding: 0.75rem;
    text-align: left;
    border: 1px solid var(--border-color);
}
         
        .data-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .data-table th, .data-table td {
            padding: 0.75rem;
            text-align: left;
            border-bottom: 1px solid var(--border-color);
        }
        
        .data-table th {
            background-color: var(--light-gray);
            font-weight: 600;
            color: var(--primary-color);
        }
        
        .data-table tr:hover {
            background-color: rgba(44, 125, 160, 0.05);
        }
         
        .analysis-summary {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
            gap: 1.5rem;
            margin: 2rem 0;
        }
        
        .analysis-item {
            background: white;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .analysis-item h4 {
            font-size: 1rem;
            color: var(--text-muted);
            margin-bottom: 0.5rem;
        }
        
        .analysis-item .value {
            font-size: 1.5rem;
            font-weight: 700;
            color: var(--primary-color);
        }
        
        .analysis-item .detail {
            font-size: 0.9rem;
            color: var(--text-muted);
            margin-top: 0.5rem;
        }
         
        .biology-info-box {
            background-color: rgba(25, 135, 84, 0.05);
            border-left: 3px solid var(--biology-green);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
         
        
        @media (max-width: 768px) { 
            .analysis-summary {
                grid-template-columns: 1fr;
            }
            
            .data-table {
                display: block;
                overflow-x: auto;
            }
        }
         
        
        .qpcr-chart-container {
            position: relative;
            height: 350px;
            width: 100%;
            margin: 1.5rem 0;
        }
        
        .qpcr-status-indicator {
            display: inline-block;
            width: 12px;
            height: 12px;
            border-radius: 50%;
            margin-right: 8px;
        }
        
        .status-upregulated {
            background-color: var(--danger-color);
        }
        
        .status-downregulated {
            background-color: var(--biology-blue);
        }
        
        .status-unchanged {
            background-color: #6c757d;
        }
        
        .add-sample-btn {
            margin-top: 1rem;
            margin-bottom: 1.5rem;
        }
        
        .sample-actions {
            display: flex;
            justify-content: flex-end;
            margin-bottom: 1rem;
        }
        
        .control-badge {
            display: inline-block;
            background-color: var(--biology-blue);
            color: white;
            padding: 0.25rem 0.5rem;
            border-radius: 4px;
            font-size: 0.75rem;
            font-weight: 600;
            margin-left: 0.5rem;
        }
        
        .delete-sample-btn {
            color: var(--danger-color);
            background: none;
            border: none;
            cursor: pointer;
            font-size: 1.2rem;
            padding: 0 0.5rem;
        }
        
        .batch-import-container {
            margin-bottom: 2rem;
        }
        
        .import-options {
            display: flex;
            gap: 1rem;
            margin-bottom: 1rem;
            flex-wrap: wrap;
        }
        
        .import-btn {
            display: flex;
            align-items: center;
        }
        
        .import-preview {
            max-height: 300px;
            overflow-y: auto;
            margin-top: 1rem;
        }
        
        .import-error {
            color: var(--danger-color);
            margin-top: 0.5rem;
        }
        
        .plate-selector {
            margin-bottom: 1.5rem;
        }
        
        .plate-tabs {
            display: flex;
            flex-wrap: wrap;
            gap: 0.5rem;
            margin-bottom: 1rem;
        }
        
        .plate-tab {
            padding: 0.5rem 1rem;
            background-color: var(--light-gray);
            border: 1px solid var(--border-color);
            border-radius: 4px;
            cursor: pointer;
            transition: all 0.3s;
        }
        
        .plate-tab.active {
            background-color: var(--primary-color);
            color: white;
            border-color: var(--primary-color);
        }
        
        .plate-tab:hover:not(.active) {
            background-color: rgba(44, 125, 160, 0.1);
        }
        
        .plate-badge {
            background-color: var(--biology-purple);
            color: white;
            padding: 0.25rem 0.5rem;
            border-radius: 4px;
            font-size: 0.75rem;
            margin-left: 0.5rem;
        }
        
        .stats-container {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
            gap: 1rem;
            margin: 1.5rem 0;
        }
        
        .stat-card {
            background: white;
            border-radius: 8px;
            padding: 1rem;
            border: 1px solid var(--border-color);
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .stat-value {
            font-size: 1.5rem;
            font-weight: 700;
            color: var(--primary-color);
        }
        
        .stat-label {
            color: var(--text-muted);
            font-size: 0.9rem;
        }
        
        .stat-stddev {
            font-size: 0.8rem;
            color: var(--text-muted);
            margin-top: 0.25rem;
        }
        
        .error-bar {
            display: inline-block;
            margin-left: 0.5rem;
            font-size: 0.9rem;
            color: var(--text-muted);
        }
        
        .replicate-group {
            background-color: rgba(13, 110, 253, 0.05);
            border-left: 3px solid var(--biology-blue);
        }
        
        .replicate-row {
            background-color: rgba(13, 110, 253, 0.02);
        }
        
        .modal-overlay {
            display: none;
            position: fixed;
            top: 0;
            left: 0;
            width: 100%;
            height: 100%;
            background-color: rgba(0, 0, 0, 0.5);
            z-index: 1000;
        }
        
        .modal-content {
            position: absolute;
            top: 50%;
            left: 50%;
            transform: translate(-50%, -50%);
            background-color: white;
            padding: 2rem;
            border-radius: 8px;
            max-width: 600px;
            width: 90%;
            max-height: 80vh;
            overflow-y: auto;
        }
        
        .file-upload-area {
            border: 2px dashed var(--border-color);
            border-radius: 8px;
            padding: 2rem;
            text-align: center;
            margin-bottom: 1rem;
            cursor: pointer;
            transition: all 0.3s;
        }
        
        .file-upload-area:hover {
            border-color: var(--primary-color);
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        .file-upload-area.dragover {
            border-color: var(--primary-color);
            background-color: rgba(44, 125, 160, 0.1);
        }
        
        .tooltip-custom {
            position: relative;
            display: inline-block;
            cursor: help;
        }
        
        .tooltip-custom .tooltip-text {
            visibility: hidden;
            width: 300px;
            background-color: #555;
            color: #fff;
            text-align: center;
            border-radius: 6px;
            padding: 10px;
            position: absolute;
            z-index: 1;
            bottom: 125%;
            left: 50%;
            margin-left: -150px;
            opacity: 0;
            transition: opacity 0.3s;
            font-size: 0.9rem;
            font-weight: normal;
        }
        
        .tooltip-custom:hover .tooltip-text {
            visibility: visible;
            opacity: 1;
        }
        
        /* 新增样式 */
        .toast {
            position: fixed;
            bottom: 20px;
            right: 20px;
            z-index: 1050;
            min-width: 300px;
        }
        
        .data-quality-alert {
            background-color: rgba(255, 193, 7, 0.1);
            border-left: 3px solid var(--warning-color);
            padding: 0.75rem;
            border-radius: 0 4px 4px 0;
            margin: 1rem 0;
        }
        
        .quality-check {
            display: flex;
            align-items: center;
            margin-bottom: 0.5rem;
        }
        
        .quality-check i {
            margin-right: 0.5rem;
        }
        
        .quality-check.good {
            color: var(--success-color);
        }
        
        .quality-check.warning {
            color: var(--warning-color);
        }
        
        .quality-check.error {
            color: var(--danger-color);
        }