:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --danger-color: #dc3545;
            --bio-green: #198754;
            --bio-blue: #0d6efd;
            --bio-purple: #6f42c1;
        }
          
        
        /* Sequence Visualization */
        .sequence-container {
            font-family: 'Courier New', monospace;
            background-color: #f8f9fa;
            padding: 1rem;
            border-radius: 6px;
            border: 1px solid #dee2e6;
            margin: 1rem 0;
            overflow-x: auto;
            white-space: nowrap;
        }
        
        .sequence-base {
            display: inline-block;
            width: 20px;
            height: 28px;
            text-align: center;
            line-height: 28px;
            font-weight: bold;
            margin: 0 1px;
            border-radius: 3px;
        }
        
        .base-A { background-color: #4CAF50; color: white; }
        .base-U, .base-T { background-color: #2196F3; color: white; }
        .base-C { background-color: #FF9800; color: white; }
        .base-G { background-color: #9C27B0; color: white; }
        
        /* Chart Container */
        .chart-container {
            position: relative;
            height: 300px;
            width: 100%;
            margin: 2rem 0;
        }
        
        /* Financial Summary */
        .financial-summary {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
            gap: 1.5rem;
            margin: 2rem 0;
        }
        
        .financial-item {
            background: white;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .financial-item h4 {
            font-size: 1rem;
            color: var(--text-muted);
            margin-bottom: 0.5rem;
        }
        
        .financial-item .value {
            font-size: 1.5rem;
            font-weight: 700;
            color: var(--primary-color);
        }
        
        .financial-item .detail {
            font-size: 0.9rem;
            color: var(--text-muted);
            margin-top: 0.5rem;
        }
         
        .bio-info-box {
            background-color: rgba(25, 135, 84, 0.05);
            border-left: 3px solid var(--bio-green);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
        
        .caution-box {
            background-color: rgba(255, 193, 7, 0.05);
            border-left: 3px solid var(--warning-color);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
         
        /* Responsive Adjustments */
        @media (max-width: 768px) { 
            .financial-summary {
                grid-template-columns: 1fr;
            }
        }
        
        /* Toggle switch for calculation modes */
        .calculation-modes {
            display: flex;
            background-color: var(--light-gray);
            border-radius: 6px;
            padding: 4px;
            margin-bottom: 1.5rem;
            flex-wrap: wrap;
        }
        
        .mode-btn {
            flex: 1;
            text-align: center;
            padding: 0.75rem;
            border-radius: 4px;
            cursor: pointer;
            transition: all 0.3s;
            font-weight: 600;
            min-width: 120px;
            margin: 2px;
        }
        
        .mode-btn.active {
            background-color: var(--primary-color);
            color: white;
        }
        
        /* Toast notifications */
        .toast-container {
            position: fixed;
            bottom: 20px;
            right: 20px;
            z-index: 1050;
        }
        
        /* Action buttons */
        .action-btn {
            background-color: white;
            border: 1px solid var(--border-color);
            border-radius: 6px;
            padding: 0.5rem 1rem;
            margin-left: 0.5rem;
            transition: all 0.3s;
            color: var(--text-color);
        }
        
        .action-btn:hover {
            background-color: var(--light-gray);
            color: var(--primary-color);
        }
        
        /* siRNA specific styling */
        .sirna-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .sirna-table th, .sirna-table td {
            padding: 0.75rem;
            text-align: left;
            border-bottom: 1px solid var(--border-color);
        }
        
        .sirna-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .sirna-table tr:hover {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        .sirna-score {
            display: inline-block;
            padding: 0.25rem 0.5rem;
            border-radius: 4px;
            font-weight: 600;
            font-size: 0.9rem;
        }
        
        .score-high {
            background-color: rgba(40, 167, 69, 0.1);
            color: var(--bio-green);
        }
        
        .score-medium {
            background-color: rgba(255, 193, 7, 0.1);
            color: var(--warning-color);
        }
        
        .score-low {
            background-color: rgba(220, 53, 69, 0.1);
            color: var(--danger-color);
        }
        
        .sequence-row {
            font-family: 'Courier New', monospace;
            font-weight: bold;
            letter-spacing: 1px;
        }
        
        .filter-controls {
            background-color: var(--light-gray);
            border-radius: 6px;
            padding: 1rem;
            margin-bottom: 1.5rem;
        }
        
        .parameter-badge {
            display: inline-block;
            padding: 0.25rem 0.5rem;
            border-radius: 4px;
            font-size: 0.8rem;
            margin-right: 0.5rem;
            margin-bottom: 0.5rem;
        }
        
        .parameter-good {
            background-color: rgba(40, 167, 69, 0.1);
            color: var(--bio-green);
            border: 1px solid rgba(40, 167, 69, 0.3);
        }
        
        .parameter-warning {
            background-color: rgba(255, 193, 7, 0.1);
            color: var(--warning-color);
            border: 1px solid rgba(255, 193, 7, 0.3);
        }
        
        .parameter-bad {
            background-color: rgba(220, 53, 69, 0.1);
            color: var(--danger-color);
            border: 1px solid rgba(220, 53, 69, 0.3);
        }
        
        .download-options {
            display: flex;
            flex-wrap: wrap;
            gap: 0.5rem;
            margin-top: 1rem;
        }
        
        .generating-indicator {
            display: none;
            text-align: center;
            padding: 1rem;
            color: var(--text-muted);
        }
        
        .sirna-details {
            display: none;
            background-color: white;
            border-radius: 6px;
            padding: 1.5rem;
            margin-top: 1rem;
            border: 1px solid var(--border-color);
        }
        
        .sirna-details.active {
            display: block;
        }
        
        .thermodynamic-chart {
            height: 200px;
            margin: 1rem 0;
        }
        
        /* Mode-specific form styling */
        .mode-form {
            display: none;
        }
        
        .mode-form.active {
            display: block;
        }