:root {
            --primary-color: #2c7da0;
            --secondary-color: #a9d6e5;
            --accent-color: #01497c;
            --light-gray: #f8f9fa;
            --border-color: #eaeaea;
            --text-color: #333;
            --text-muted: #6c757d;
            --success-color: #28a745;
            --warning-color: #ffc107;
            --dna-blue: #0d6efd;
            --tf-green: #20c997;
            --promoter-orange: #fd7e14;
            --enhancer-purple: #6f42c1;
            --significant-red: #dc3545;
        }
         
        
        /* Professional styling additions */
        .advanced-feature {
            border-left: 4px solid var(--significant-red);
            background-color: rgba(220, 53, 69, 0.05);
            padding: 1rem;
            margin: 1rem 0;
            border-radius: 0 4px 4px 0;
        }
        
        .pwm-matrix {
            font-family: 'Courier New', monospace;
            background-color: #f8f9fa;
            padding: 1rem;
            border-radius: 4px;
            overflow-x: auto;
            margin: 1rem 0;
        }
        
        .pwm-cell {
            display: inline-block;
            width: 40px;
            text-align: center;
            padding: 2px;
            margin: 1px;
            border-radius: 2px;
            font-size: 0.8rem;
            font-weight: bold;
        }
        
        .pwm-positive {
            background-color: rgba(40, 167, 69, 0.2);
            color: #155724;
        }
        
        .pwm-negative {
            background-color: rgba(220, 53, 69, 0.2);
            color: #721c24;
        }
        
        .pwm-neutral {
            background-color: rgba(108, 117, 125, 0.1);
            color: #495057;
        }
        
        .statistical-value {
            font-family: 'Courier New', monospace;
            background-color: #f8f9fa;
            padding: 0.25rem 0.5rem;
            border-radius: 3px;
            border: 1px solid #dee2e6;
        }
        
        .significance-indicator {
            display: inline-block;
            width: 12px;
            height: 12px;
            border-radius: 50%;
            margin-right: 5px;
        }
        
        .significant {
            background-color: var(--significant-red);
        }
        
        .marginally-significant {
            background-color: var(--warning-color);
        }
        
        .not-significant {
            background-color: var(--text-muted);
        }
        
        .computation-details {
            background-color: #f8f9fa;
            border-left: 3px solid var(--primary-color);
            padding: 1rem;
            margin: 1rem 0;
            border-radius: 0 4px 4px 0;
            font-size: 0.9rem;
        }
        
        .algorithm-explanation {
            background-color: rgba(13, 110, 253, 0.05);
            border: 1px solid rgba(13, 110, 253, 0.2);
            border-radius: 4px;
            padding: 1rem;
            margin: 1rem 0;
        }
        
        /* Heatmap styling for PWM visualization */
        .heatmap-container {
            width: 100%;
            overflow-x: auto;
            margin: 1rem 0;
        }
        
        .heatmap-row {
            display: flex;
            height: 30px;
            margin-bottom: 2px;
        }
        
        .heatmap-cell {
            flex: 1;
            display: flex;
            align-items: center;
            justify-content: center;
            font-size: 0.8rem;
            font-weight: bold;
            color: white;
            min-width: 30px;
        }
        
        /* TFBS specific styles */
        .tfbs-stats {
            display: grid;
            grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
            gap: 1.5rem;
            margin: 2rem 0;
        }
        
        .stat-item {
            background: white;
            border-radius: 8px;
            padding: 1.5rem;
            border: 1px solid var(--border-color);
            box-shadow: 0 2px 4px rgba(0,0,0,0.05);
        }
        
        .stat-item h4 {
            font-size: 1rem;
            color: var(--text-muted);
            margin-bottom: 0.5rem;
        }
        
        .stat-item .value {
            font-size: 1.5rem;
            font-weight: 700;
            color: var(--tf-green);
        }
        
        .stat-item .detail {
            font-size: 0.9rem;
            color: var(--text-muted);
            margin-top: 0.5rem;
        }
        
        /* Score visualization */
        .score-bar {
            height: 10px;
            background-color: #e9ecef;
            border-radius: 5px;
            margin: 5px 0;
            overflow: hidden;
        }
        
        .score-fill {
            height: 100%;
            border-radius: 5px;
        }
        
        .high-score {
            background-color: var(--success-color);
        }
        
        .medium-score {
            background-color: var(--warning-color);
        }
        
        .low-score {
            background-color: #6c757d;
        }
        
        /* Results table */
        .results-table {
            width: 100%;
            border-collapse: collapse;
            margin: 1.5rem 0;
        }
        
        .results-table th, .results-table td {
            padding: 0.75rem;
            text-align: left;
            border-bottom: 1px solid var(--border-color);
        }
        
        .results-table th {
            background-color: var(--light-gray);
            font-weight: 600;
        }
        
        .results-table tr:hover {
            background-color: rgba(44, 125, 160, 0.05);
        }
        
        /* Bioinfo-specific styling */
        .bioinfo-box {
            background-color: rgba(32, 201, 151, 0.05);
            border-left: 3px solid var(--tf-green);
            padding: 1rem;
            border-radius: 0 4px 4px 0;
            margin: 1.5rem 0;
        }
        
        .bioinfo-alert {
            background-color: rgba(32, 201, 151, 0.1);
            border-left: 4px solid var(--tf-green);
            padding: 1rem;
            margin: 1rem 0;
            border-radius: 0 4px 4px 0;
        }